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Calcium phosphate cements (CPCs) were prepared by using Ca4(PO4)20 (TeCP), modified CaHPO4(DCPA) and polysaccharide of Dextran Sulfate Sodium (DSS) for the application of medical clinical devices. The setting behavior such as setting time and operable time were controlled by mainly the primary particle size and its aggregate morphology of DCPA. The disintegration behavior in liquid of CPC paste and the plastic formability were improved by adding polysaccharide of DSS. The injection syringe for the CPC was also developed as medical device suitable for clinical application. The developed CPC hasbeen being used for patients with bone disease to improve the quality of life.
形態付与型リン酸カルシウム系骨補填材の開発(生体活性骨ペーストの開発)
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