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Perkin transactions 1"}]}]}, "item_10001_description_36": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "The crystal structures of the isovaline-containing dipeptides, Boc-D-Iva-L-Pro-NHBzl 4 and Boc-L-Iva-L-Pro-NHBzl 5 were determined by X-ray diffraction. The diastereoisomeric peptides adopt intramolecular hydrogen-bonded β-turn conformations closely similar to each other (4:φIva-51°, ψIva-38°, φPro-70° and ψPro-17° and 5: φIva-53°, ψIva-35°, φPro-72° and ψPro-14°). The Pro ring of each peptide is in Cγ-exo conformation. These conformations are essentially the same as those in the reported crystal structures of the Aib-L-Pro sequence possessing an NH group directly attached to the carbonyl of the L-Pro, indicating that replacement of either one of the two methyl groups of the Aib moiety with an ethyl group does not cause any significant change in the β-turn conformation of the Aib-L-Pro sequence in the crystalline state.CD spectral analysis of the terminal chromophoric group-carrying peptides Dnp-Gly-X-L-Pro-Gly-pNA (X = Aib 6 and D/L-Iva 7/8) has shown that these three tetrapeptides in CHCl3 and THF solutions also adopt a β-turn-type conformation. CD spectra of glycolic acid residue-containing analogues in place of the fourth Gly residue revealed a lack of β-turn tendency in these analogues, indicating the importance of intramolecular hydrogen bonding for the β-turn conformation of the central dipeptide moieties. The results are consistent with the reported unturned crystal structures of Aib-L-Pro arid D/L-Iva-L-Pro sequence-containing peptides lacking the NH group which directly follows the Pro residue available for intramolecular hydrogen bonding.", "subitem_description_type": "Other"}]}, "item_10001_description_38": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10001_full_name_27": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "8643", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000080220440", "nameIdentifierScheme": "NRID", "nameIdentifierURI": "http://rns.nii.ac.jp/nr/1000080220440"}], "names": [{"name": "山村, 初雄"}]}]}, "item_10001_publisher_29": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Royal Society of Chemistry"}]}, "item_10001_relation_34": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1039/P19950002115"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1039/P19950002115", "subitem_relation_type_select": "DOI"}}]}, "item_10001_source_id_30": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0300922X", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_source_id_32": {"attribute_name": "書誌レコードID(NCID)", "attribute_value_mlt": [{"subitem_source_identifier": "AA00695134", "subitem_source_identifier_type": "NCID"}]}, "item_10001_version_type_33": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawai, Masao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "13051", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Omori, Yoshimasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "13052", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamura, Hatsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8643", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000080220440", "nameIdentifierScheme": "NRID", "nameIdentifierURI": "http://rns.nii.ac.jp/nr/1000080220440"}]}, {"creatorNames": [{"creatorName": "Butsugan, Yasuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "10536", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taga, Toru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "13055", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miwa, Yoshihisa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "13056", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-01-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JCSP 1995_2115.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "J. CHEM. SOC. PERKIN TRANS. I 1995, 2215-2122 - Reproduced by permission of The Royal Society of Chemistry (RSC)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "本文_fulltext", "url": "https://nitech.repo.nii.ac.jp/record/4316/files/JCSP 1995_2115.pdf"}, "version_id": "36b56c31-419f-49d5-af75-8e43df17b305"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Two alternative conformational states of α,α-dialkylglycyl-L- prolyl sequences governed by presence/absence of an NH group directly following the proline residue. X-ray crystal and molecular structures of Boc-D-Iva-L-Pro-NHBzl and Boc-L-Iva-L-Pro-NHBzl", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Two alternative conformational states of α,α-dialkylglycyl-L- prolyl sequences governed by presence/absence of an NH group directly following the proline residue. X-ray crystal and molecular structures of Boc-D-Iva-L-Pro-NHBzl and Boc-L-Iva-L-Pro-NHBzl", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "3", "path": ["31"], "permalink_uri": "https://nitech.repo.nii.ac.jp/records/4316", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-11-06"}, "publish_date": "2012-11-06", "publish_status": "0", "recid": "4316", "relation": {}, "relation_version_is_last": true, "title": ["Two alternative conformational states of α,α-dialkylglycyl-L- prolyl sequences governed by presence/absence of an NH group directly following the proline residue. X-ray crystal and molecular structures of Boc-D-Iva-L-Pro-NHBzl and Boc-L-Iva-L-Pro-NHBzl"], "weko_shared_id": 3}
Two alternative conformational states of α,α-dialkylglycyl-L- prolyl sequences governed by presence/absence of an NH group directly following the proline residue. X-ray crystal and molecular structures of Boc-D-Iva-L-Pro-NHBzl and Boc-L-Iva-L-Pro-NHBzl
https://nitech.repo.nii.ac.jp/records/4316
https://nitech.repo.nii.ac.jp/records/4316f97584a1-53e3-44c6-9d5d-a835c0b70643
名前 / ファイル | ライセンス | アクション |
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本文_fulltext (1.0 MB)
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J. CHEM. SOC. PERKIN TRANS. I 1995, 2215-2122 - Reproduced by permission of The Royal Society of Chemistry (RSC)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-11-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Two alternative conformational states of α,α-dialkylglycyl-L- prolyl sequences governed by presence/absence of an NH group directly following the proline residue. X-ray crystal and molecular structures of Boc-D-Iva-L-Pro-NHBzl and Boc-L-Iva-L-Pro-NHBzl | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawai, Masao
× Kawai, Masao× Omori, Yoshimasa× Yamamura, Hatsuo× Butsugan, Yasuo× Taga, Toru× Miwa, Yoshihisa |
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著者別名 | ||||||
姓名 | 山村, 初雄 | |||||
書誌情報 |
Journal of the Chemical Society. Perkin transactions 1 巻 1995, 号 17, p. 2115-2122, 発行日 1995-01-01 |
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出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0300922X | |||||
書誌レコードID(NCID) | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695134 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1039/P19950002115 | |||||
関連名称 | 10.1039/P19950002115 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The crystal structures of the isovaline-containing dipeptides, Boc-D-Iva-L-Pro-NHBzl 4 and Boc-L-Iva-L-Pro-NHBzl 5 were determined by X-ray diffraction. The diastereoisomeric peptides adopt intramolecular hydrogen-bonded β-turn conformations closely similar to each other (4:φIva-51°, ψIva-38°, φPro-70° and ψPro-17° and 5: φIva-53°, ψIva-35°, φPro-72° and ψPro-14°). The Pro ring of each peptide is in Cγ-exo conformation. These conformations are essentially the same as those in the reported crystal structures of the Aib-L-Pro sequence possessing an NH group directly attached to the carbonyl of the L-Pro, indicating that replacement of either one of the two methyl groups of the Aib moiety with an ethyl group does not cause any significant change in the β-turn conformation of the Aib-L-Pro sequence in the crystalline state.CD spectral analysis of the terminal chromophoric group-carrying peptides Dnp-Gly-X-L-Pro-Gly-pNA (X = Aib 6 and D/L-Iva 7/8) has shown that these three tetrapeptides in CHCl3 and THF solutions also adopt a β-turn-type conformation. CD spectra of glycolic acid residue-containing analogues in place of the fourth Gly residue revealed a lack of β-turn tendency in these analogues, indicating the importance of intramolecular hydrogen bonding for the β-turn conformation of the central dipeptide moieties. The results are consistent with the reported unturned crystal structures of Aib-L-Pro arid D/L-Iva-L-Pro sequence-containing peptides lacking the NH group which directly follows the Pro residue available for intramolecular hydrogen bonding. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |